Biological Activity
High affinity negative allosteric modulator at the mGlu5 receptor (Ki = 0.67 nM). Potently inhibits mGlu5 glutamate-mediated calcium mobilization (IC50 = 1.22 nM). Inhibits cocaine-taking and cocaine-seeking behavior in rats.
Technical Data
| M. Wt | 272.7 |
| Formula | C15H9FN2.HCl |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 1224431-15-5 |
| PubChem ID | 90488944 |
| InChI Key | WRHOKQFFLQKKNL-UHFFFAOYSA-N |
| Smiles | CC1=NC(C#CC2=CC(C#N)=CC(F)=C2)=CC=C1.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
All Tocris products are intended for laboratory research use only.
Solubility Data
| DMSO | 27.27 | 100 |
| ethanol | 27.27 | 100 |
Preparing Stock Solutions
The following data is based on the product molecular weight 272.7. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 1 mM | 3.67 mL | 18.34 mL | 36.67 mL |
| 5 mM | 0.73 mL | 3.67 mL | 7.33 mL |
| 10 mM | 0.37 mL | 1.83 mL | 3.67 mL |
| 50 mM | 0.07 mL | 0.37 mL | 0.73 mL |
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Certificate of Analysis / Product Datasheet Safety Datasheet Select another language: English German French Spanish View SDSReferences
References are publications that support the products\' biological activity.
Alagille et al (2011) Potent mGluR5 antagonists: pyridyl and thiazolyl-ethynyl-3,5-disubstituted-phenyl series. Bioorg.Med.Chem.Lett. 21 3243 PMID: 21546249
Keck et al (2012) Metabotropic glutamate receptor 5 negative allosteric modulators as novel tools for in vivo investigation. ACS Med.Chem.Lett. 3 544 PMID: 22924094
Keck et al (2014) A novel mGluR5 antagonist, MFZ 10-7, inhibits cocaine-taking and cocaine-seeking behavior in rats. Addict.Biol. 19 195 PMID: 24001208
Keywords: MFZ 10-7, supplier, MFZ107, high, affinity, negative, allosteric, modulators, nams, mglur5, metabotropic, glutamate, receptors, nams, Glutamate, (Metabotropic), Group, I, Receptors, Glutamate, (Metabotropic), Group, I, Receptors, Tocris Bioscience
