Inhibitorofthechymotrypsin-likeactivityofthe20Sproteasome(IC50~1μM).Displaysanticanceractivity;inhibitscellgrowthinhumancoloncancerHCT116p53+/+cells(IC50=1.49μM).
SoldwiththepermissionofJohnsHopkinsUniversity
M.Wt | 377.01 |
Formula | C20H21B2NO5 |
Storage | Storeat+4°C |
Purity | ≥97%(HPLC) |
CASNumber | 856849-35-9 |
PubChemID | 11639443 |
InChIKey | SRPIKXGUPAKTIZ-OTYYAQKOSA-N |
Smiles | O=C(/C(CN(C)C3)=C/C2=CC=C(B(O)O)C=C2)/C3=C/C1=CC=C(B(O)O)C=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 3.77 | 10 |
Thefollowingdataisbasedontheproductmolecularweight377.01.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.65mL | 13.26mL | 26.52mL |
5mM | 0.53mL | 2.65mL | 5.3mL |
10mM | 0.27mL | 1.33mL | 2.65mL |
50mM | 0.05mL | 0.27mL | 0.53mL |