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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/AS 1949490/3718/10/10 mg
产品编号:3718/10
市  场 价:¥3100.00
场      地:美国(厂家直采)
产品分类: 蛋白类>>蛋白酶类>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$155.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/AS 1949490/3718/10/10 mg
商品介绍
Description:SH2domain-containinginositol5'-phosphatase2(SHIP2)inhibitor
ChemicalName:3-[(4-Chlorophenyl)methoxy]-N-[(1S)-1-phenylethyl]thiophene-2-carboxamide
Purity:≥99%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

SelectiveSHIP2(SH2domain-containinginositol5'-phosphatase2)inhibitor(IC50valuesare0.34μMand0.62μMformouseandhumanrespectively);displaysapproximately30-foldaffinityforSHIP2overSHIP1.Increasesinsulin-inducedphosphorylationofAktinL6myotubules.Stimulatesactivationofglucosemetabolism;regulatesgluconeogenesisinvitroandinvivoandexhibitsantidiabeticeffects.

CompoundLibraries

AS1949490isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt371.88
FormulaC20H18ClNO2S
StorageStoreatRT
Purity≥99%(HPLC)
CASNumber1203680-76-5
PubChemID44473434
InChIKeyRFZPGNRLOKVZJY-AWEZNQCLSA-N
SmilesClC(C=C2)=CC=C2COC1=C(C(N[C@@H](C)C3=CC=CC=C3)=O)SC=C1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO37.19100
ethanol37.19100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight371.88.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM2.69mL13.45mL26.89mL
5mM0.54mL2.69mL5.38mL
10mM0.27mL1.34mL2.69mL
50mM0.05mL0.27mL0.54mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet