SelectiveSHIP2(SH2domain-containinginositol5'-phosphatase2)inhibitor(IC50valuesare0.34μMand0.62μMformouseandhumanrespectively);displaysapproximately30-foldaffinityforSHIP2overSHIP1.Increasesinsulin-inducedphosphorylationofAktinL6myotubules.Stimulatesactivationofglucosemetabolism;regulatesgluconeogenesisinvitroandinvivoandexhibitsantidiabeticeffects.
AS1949490isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
M.Wt | 371.88 |
Formula | C20H18ClNO2S |
Storage | StoreatRT |
Purity | ≥99%(HPLC) |
CASNumber | 1203680-76-5 |
PubChemID | 44473434 |
InChIKey | RFZPGNRLOKVZJY-AWEZNQCLSA-N |
Smiles | ClC(C=C2)=CC=C2COC1=C(C(N[C@@H](C)C3=CC=CC=C3)=O)SC=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 37.19 | 100 | |
ethanol | 37.19 | 100 |
Thefollowingdataisbasedontheproductmolecularweight371.88.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.69mL | 13.45mL | 26.89mL |
5mM | 0.54mL | 2.69mL | 5.38mL |
10mM | 0.27mL | 1.34mL | 2.69mL |
50mM | 0.05mL | 0.27mL | 0.54mL |