DimericSmacmimetic;potentinhibitorofX-linked(XIAP)andcellular(cIAP)inhibitorofapoptosisprotein(IC50valuesare15,15and21nMforXIAP,cIAP1andcIAP2respectively).BindstotheBIR3domainofXIAPtopreventinteractionwithcaspase-9.CausesdegradationofcIAP1andcIAP2andinducesapoptosisinMDA-MB-231breastcancercells.CausestumorregressioninMDA-MB-231xenograft-bearingmice.
SoldwiththepermissionofAstraZenecaUKLtd
M.Wt | 1088.21 |
Formula | C58H78N8O8.2HCl |
Storage | Storeat-20°C |
Purity | ≥97%(HPLC) |
PubChemID | 90489014 |
InChIKey | DAILKFFMJFAUCE-GXSVUDMFSA-N |
Smiles | CN[C@@H](C)C(N[C@@H]([C@H]1CCCCC1)C(N2[C@H]([C@](N[C@H]3C(C=CC=C5)=C5C[C@H]3OCC#CC#CCO[C@@H]4CC8=C(C=CC=C8)[C@@H]4N[C@@]([C@H](CCC7)N7C([C@H]([C@H]6CCCCC6)NC([C@H](C)NC)=O)=O)=O)=O)CCC2)=O)=O.Cl.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 108.82 | 100 | |
water | 108.82 | 100 |
Thefollowingdataisbasedontheproductmolecularweight1088.21.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 0.92mL | 4.59mL | 9.19mL |
5mM | 0.18mL | 0.92mL | 1.84mL |
10mM | 0.09mL | 0.46mL | 0.92mL |
50mM | 0.02mL | 0.09mL | 0.18mL |