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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/AZD 5582 dihydrochloride/5141/50/50 mg
产品编号:5141/50
市  场 价:¥21700.00
场      地:美国(厂家直采)
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$1085.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/AZD 5582 dihydrochloride/5141/50/50 mg
商品介绍
Description:DimericSmacmimetic;potentIAPinhibitor
ChemicalName:3,3'-[2,4-HexADIyne-1,6-diylbis[oxy[(1S,2R)-2,3-dihydro-1H-indene-2,1-diyl]]]bis[N-methyl-L-alanyl-(2S)-2-cyclohexylglycyl-L-prolinamide
Purity:≥97%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

DimericSmacmimetic;potentinhibitorofX-linked(XIAP)andcellular(cIAP)inhibitorofapoptosisprotein(IC50valuesare15,15and21nMforXIAP,cIAP1andcIAP2respectively).BindstotheBIR3domainofXIAPtopreventinteractionwithcaspase-9.CausesdegradationofcIAP1andcIAP2andinducesapoptosisinMDA-MB-231breastcancercells.CausestumorregressioninMDA-MB-231xenograft-bearingmice.

LicensingInformation

SoldwiththepermissionofAstraZenecaUKLtd

TechnicalData

M.Wt1088.21
FormulaC58H78N8O8.2HCl
StorageStoreat-20°C
Purity≥97%(HPLC)
PubChemID90489014
InChIKeyDAILKFFMJFAUCE-GXSVUDMFSA-N
SmilesCN[C@@H](C)C(N[C@@H]([C@H]1CCCCC1)C(N2[C@H]([C@](N[C@H]3C(C=CC=C5)=C5C[C@H]3OCC#CC#CCO[C@@H]4CC8=C(C=CC=C8)[C@@H]4N[C@@]([C@H](CCC7)N7C([C@H]([C@H]6CCCCC6)NC([C@H](C)NC)=O)=O)=O)=O)CCC2)=O)=O.Cl.Cl

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO108.82100
water108.82100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight1088.21.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM0.92mL4.59mL9.19mL
5mM0.18mL0.92mL1.84mL
10mM0.09mL0.46mL0.92mL
50mM0.02mL0.09mL0.18mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet