Potentandselectivediacylglycerolacyltransferase(DGAT-1)inhibitor(IC50=0.6nM).ExhibitsselectivityforDGAT-1overDGAT-2,Kv11.1(hERG)andcytochromeP450enzymes.Suppressestriacylglyceride(TAG)plasmaexcursionandadiposetissueTAGsynthesisinrats.Reducesbodyweightofdiet-inducedobeserats.Cellpermeableandorallybioavailable.
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M.Wt | 456.44 |
Formula | C23H22F2N4O4 |
Storage | Storeat+4°C |
Purity | ≥98%(HPLC) |
CASNumber | 892489-52-0 |
PubChemID | 11676786 |
InChIKey | ZGBGPEDJXCYQPH-UHFFFAOYSA-N |
Smiles | O=C(NC3=CC=[C@@]([C@H]4CC[C@H](CC(O)=O)CC4)C=C3)C1=NN=C(NC2=CC(F)=C(F)C=C2)O1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
1eq.NaOH | 4.56 | 10mMwithgentlewarming | |
DMSO | 45.64 | 100 |
Thefollowingdataisbasedontheproductmolecularweight456.44.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.19mL | 10.95mL | 21.91mL |
5mM | 0.44mL | 2.19mL | 4.38mL |
10mM | 0.22mL | 1.1mL | 2.19mL |
50mM | 0.04mL | 0.22mL | 0.44mL |