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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/AZD 3988/4837/10/10 mg
产品编号:4837/10
市  场 价:¥6180.00
场      地:美国(厂家直采)
产品分类: 蛋白类>>其它酶>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$309.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/AZD 3988/4837/10/10 mg
商品介绍
Description:PotentandselectiveDGAT-1inhibitor
ChemicalName:trans-4-[-[[[5-[(3,4-Difluorophenyl)amino]-1,3,4-oxADIazol-2-yl]carbonyl]amino]phenyl]cyclohexaneaceticacid
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Potentandselectivediacylglycerolacyltransferase(DGAT-1)inhibitor(IC50=0.6nM).ExhibitsselectivityforDGAT-1overDGAT-2,Kv11.1(hERG)andcytochromeP450enzymes.Suppressestriacylglyceride(TAG)plasmaexcursionandadiposetissueTAGsynthesisinrats.Reducesbodyweightofdiet-inducedobeserats.Cellpermeableandorallybioavailable.

LicensingInformation

SoldwiththepermissionofAstraZenecaUKLtd.

CompoundLibraries

AZD3988isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt456.44
FormulaC23H22F2N4O4
StorageStoreat+4°C
Purity≥98%(HPLC)
CASNumber892489-52-0
PubChemID11676786
InChIKeyZGBGPEDJXCYQPH-UHFFFAOYSA-N
SmilesO=C(NC3=CC=[C@@]([C@H]4CC[C@H](CC(O)=O)CC4)C=C3)C1=NN=C(NC2=CC(F)=C(F)C=C2)O1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
1eq.NaOH4.5610mMwithgentlewarming
DMSO45.64100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight456.44.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM2.19mL10.95mL21.91mL
5mM0.44mL2.19mL4.38mL
10mM0.22mL1.1mL2.19mL
50mM0.04mL0.22mL0.44mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet