InhibitorofHedgehog(Hh)signaling(IC50<0.012μMinafireflyreporterassayagainsttheHhpathway).ShowntodisplacecyclopamineinHeLacellsexpressingSmoothened.Exhibitsselectivityagainstp38α.Orallybioavailable.
SoldwiththepermissionofAstraZenecaUKLtd.
AZ12080282dihydrochlorideisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
| M.Wt | 457.35 |
| Formula | C23H20N4O2.2HCl |
| Storage | DesiccateatRT |
| Purity | ≥98%(HPLC) |
| PubChemID | 78243727 |
| InChIKey | CPORFOBFIDPDLZ-UHFFFAOYSA-N |
| Smiles | CC1=CC=C(C2=NC=CN2)C=C1NC(C3=CC=C(OCC4=CC=CC=N4)C=C3)=O.Cl.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 45.73 | 100 | |
| water | 45.73 | 100 |
Thefollowingdataisbasedontheproductmolecularweight457.35.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.19mL | 10.93mL | 21.87mL |
| 5mM | 0.44mL | 2.19mL | 4.37mL |
| 10mM | 0.22mL | 1.09mL | 2.19mL |
| 50mM | 0.04mL | 0.22mL | 0.44mL |



