Inhibitorofhedgehog(Hh)signaling,possIBLyviaseveralmechanisms.InhibitsΔ7-dehydrocholesterolreductase(IC50=13nM),thusreducescholesterolbiosynthesis,andalsoinhibitscholesterolesterification.MayalsodirectlyblockthecellularresponsetoHhproteins.Teratogenicinvivo.
M.Wt | 464.3 |
Formula | C22H28Cl2N2.2HCl |
Storage | DesiccateatRT |
Purity | ≥99%(HPLC) |
CASNumber | 366-93-8 |
PubChemID | 9954082 |
InChIKey | GZFYZYBWLCYBMI-MYZJJQSMSA-N |
Smiles | ClC(C=CC=C3)=C3CNC[C@H]1CC[C@H](CNCC2=C(Cl)C=CC=C2)CC1.Cl.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 2.32 | 5 | |
water | 23.21 | 50 |
Thefollowingdataisbasedontheproductmolecularweight464.3.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.15mL | 10.77mL | 21.54mL |
5mM | 0.43mL | 2.15mL | 4.31mL |
10mM | 0.22mL | 1.08mL | 2.15mL |
50mM | 0.04mL | 0.22mL | 0.43mL |