请使用支持JavaScript的浏览器!
主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/AY 9944 dihydrochloride/1639/10/10 mg
产品编号:1639/10
市  场 价:¥3300.00
场      地:美国(厂家直采)
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$165.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/AY 9944 dihydrochloride/1639/10/10 mg
商品介绍
Description:InhibitorofHedgehog(Hh)signaling.InhibitsΔ7-dehydrocholesterolreductase
ChemicalName:trans-N,N-bis[2-Chlorophenylmethyl]-1,4-cyclohexanedimethanaminedihydrochloride
Purity:≥99%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Inhibitorofhedgehog(Hh)signaling,possIBLyviaseveralmechanisms.InhibitsΔ7-dehydrocholesterolreductase(IC50=13nM),thusreducescholesterolbiosynthesis,andalsoinhibitscholesterolesterification.MayalsodirectlyblockthecellularresponsetoHhproteins.Teratogenicinvivo.

TechnicalData

M.Wt464.3
FormulaC22H28Cl2N2.2HCl
StorageDesiccateatRT
Purity≥99%(HPLC)
CASNumber366-93-8
PubChemID9954082
InChIKeyGZFYZYBWLCYBMI-MYZJJQSMSA-N
SmilesClC(C=CC=C3)=C3CNC[C@H]1CC[C@H](CNCC2=C(Cl)C=CC=C2)CC1.Cl.Cl

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO2.325
water23.2150

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight464.3.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM2.15mL10.77mL21.54mL
5mM0.43mL2.15mL4.31mL
10mM0.22mL1.08mL2.15mL
50mM0.04mL0.22mL0.43mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet