CXCR4allostericagonist(EC50=194nM).InduceschemotaxisinCXCR4-expressingcellsinvitro.Mobilizespolymorphonuclearneutrophils(PMNs)andhematopoieticstemandProgenitorcells(HSPCs)frombonemarrownicheinvivo.ExhibitsbiasedsignalingtowardsGiproteinsoverG13andβ-arrestin.
| M.Wt | 2256.82 |
| Formula | C104H178N26O25S2 |
| Sequence | MGYQKKLRSMTDKYRL (Modifications:Met-1=N-terminalPalmitoyl) |
| Storage | Storeat-20°C |
| CASNumber | 1337878-62-2 |
| PubChemID | 101961246 |
| InChIKey | YMLOFEANRZSEGQ-QNHYGVTPSA-N |
| Smiles | CCCCCCCCCCCCCCCC(=O)N[C@@H](CCSC)C(=O)NCC(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(O)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
| Solubility | Solubleto1mg/mlinwater |
Thefollowingdataisbasedontheproductmolecularweight2256.82.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 0.44mL | 2.22mL | 4.43mL |
| 5mM | 0.09mL | 0.44mL | 0.89mL |
| 10mM | 0.04mL | 0.22mL | 0.44mL |
| 50mM | 0.01mL | 0.04mL | 0.09mL |



