Orallyactiveinhibitoroflipocalin-typeprostaglandinDsynthase(L-PGDS)(Ki=75μM,IC50=95μM).InhibitstheproductionofPGD2fromPGH2invitro,withnoeffectonPGE2orPGF2αproduction.
M.Wt | 397.52 |
Formula | C25H27N5 |
Storage | Storeat-20°C |
Purity | ≥99%(HPLC) |
CASNumber | 162640-98-4 |
PubChemID | 11741525 |
InChIKey | LQNGMDUIRLSESZ-UHFFFAOYSA-N |
Smiles | C2(C=CC=C3)=C3/C(C(C=CC=C4)=C4C=C2)=C1CCN(CCCCC5=NNN=N5)CC/1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 19.88 | 50 |
Thefollowingdataisbasedontheproductmolecularweight397.52.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.52mL | 12.58mL | 25.16mL |
5mM | 0.5mL | 2.52mL | 5.03mL |
10mM | 0.25mL | 1.26mL | 2.52mL |
50mM | 0.05mL | 0.25mL | 0.5mL |