Orallyactiveinhibitoroflipocalin-typeprostaglandinDsynthase(L-PGDS)(Ki=75μM,IC50=95μM).InhibitstheproductionofPGD2fromPGH2invitro,withnoeffectonPGE2orPGF2αproduction.
| M.Wt | 397.52 |
| Formula | C25H27N5 |
| Storage | Storeat-20°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 162640-98-4 |
| PubChemID | 11741525 |
| InChIKey | LQNGMDUIRLSESZ-UHFFFAOYSA-N |
| Smiles | C2(C=CC=C3)=C3/C(C(C=CC=C4)=C4C=C2)=C1CCN(CCCCC5=NNN=N5)CC/1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 19.88 | 50 |
Thefollowingdataisbasedontheproductmolecularweight397.52.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.52mL | 12.58mL | 25.16mL |
| 5mM | 0.5mL | 2.52mL | 5.03mL |
| 10mM | 0.25mL | 1.26mL | 2.52mL |
| 50mM | 0.05mL | 0.25mL | 0.5mL |



