SelectiveTRPA1activator(EC50valuesare~0.5μMinhuman,mouseandrat).Displayslittleornoaffinityatmorethan60otherrelatedreceptors,channelsandenzymes.Stimulates5-HTreleasefromQGP-1cells.ExhibitsanaBDominalanalgesiceffectinvivo.Orallybioavailable.
| M.Wt | 263.26 |
| Formula | C14H14FNO3 |
| Storage | Storeat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 1190217-35-6 |
| PubChemID | 44232532 |
| InChIKey | RCVZUIGCNAAMIC-UXBLZVDNSA-N |
| Smiles | O=C2/C(C1=CC=CC(F)=C1N2CC(C)C)=C/C(O)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 26.33 | 100 | |
| ethanol | 26.33 | 100 |
Thefollowingdataisbasedontheproductmolecularweight263.26.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.8mL | 18.99mL | 37.99mL |
| 5mM | 0.76mL | 3.8mL | 7.6mL |
| 10mM | 0.38mL | 1.9mL | 3.8mL |
| 50mM | 0.08mL | 0.38mL | 0.76mL |



