Potentkinesinspindleprotein(KSP)inhibitor(IC50=6nM);selectiveforKSPover>250otherreceptorsandkinasesataconcentrationof10μM.Displaysrobustantitumoractivityinbortezomib-resistantxenograftseitheraloneorincombinationwithbortezomib.InducesdegradationofMcl-1;exhibitscomparablecytotoxicactivitytotaxol(Cat.No.1097)inepithelialovariancancercells.Activeinvivo.
M.Wt | 420.48 |
Formula | C20H22F2N4O2S.CF3CO2H |
Storage | Storeat-20°C |
Purity | ≥98%(HPLC) |
CASNumber | 885060-09-3 |
PubChemID | 90488964 |
InChIKey | CIJUJPVFECBUKG-BDQAORGHSA-N |
Smiles | FC1=CC=C(F)C=C1C2=NN(C(N(C)OC)=O)[C@](CCCN)([C@]3=CC=CC=C3)S2.FC(F)(F)C(O)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 31.54 | 75 | |
ethanol | 31.54 | 75 |
Thefollowingdataisbasedontheproductmolecularweight420.48.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.38mL | 11.89mL | 23.78mL |
5mM | 0.48mL | 2.38mL | 4.76mL |
10mM | 0.24mL | 1.19mL | 2.38mL |
50mM | 0.05mL | 0.24mL | 0.48mL |