Potentkinesinspindleprotein(KSP)inhibitor(IC50=6nM);selectiveforKSPover>250otherreceptorsandkinasesataconcentrationof10μM.Displaysrobustantitumoractivityinbortezomib-resistantxenograftseitheraloneorincombinationwithbortezomib.InducesdegradationofMcl-1;exhibitscomparablecytotoxicactivitytotaxol(Cat.No.1097)inepithelialovariancancercells.Activeinvivo.
| M.Wt | 420.48 |
| Formula | C20H22F2N4O2S.CF3CO2H |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 885060-09-3 |
| PubChemID | 90488964 |
| InChIKey | CIJUJPVFECBUKG-BDQAORGHSA-N |
| Smiles | FC1=CC=C(F)C=C1C2=NN(C(N(C)OC)=O)[C@](CCCN)([C@]3=CC=CC=C3)S2.FC(F)(F)C(O)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 31.54 | 75 | |
| ethanol | 31.54 | 75 |
Thefollowingdataisbasedontheproductmolecularweight420.48.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.38mL | 11.89mL | 23.78mL |
| 5mM | 0.48mL | 2.38mL | 4.76mL |
| 10mM | 0.24mL | 1.19mL | 2.38mL |
| 50mM | 0.05mL | 0.24mL | 0.48mL |



