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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/ARRY 520 trifluoroacetate/4676/10/10 mg
产品编号:4676/10
市  场 价:¥4500.00
场      地:美国(厂家直采)
产品分类: 蛋白类>>其它酶>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$225.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/ARRY 520 trifluoroacetate/4676/10/10 mg
商品介绍
Description:Potentandselectivekinesinspindleprotein(KSP)inhibitor;inducesMcl-1degradation
AlternativeNames:Filanesib
ChemicalName:(2S)-2-(3-Aminopropyl)-5-(2,5-difluorophenyl)-N-methoxy-N-methyl-2-phenyl-1,3,4-thiADIazole-3(2H)-carboxamidetrifluoroacetate
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Potentkinesinspindleprotein(KSP)inhibitor(IC50=6nM);selectiveforKSPover>250otherreceptorsandkinasesataconcentrationof10μM.Displaysrobustantitumoractivityinbortezomib-resistantxenograftseitheraloneorincombinationwithbortezomib.InducesdegradationofMcl-1;exhibitscomparablecytotoxicactivitytotaxol(Cat.No.1097)inepithelialovariancancercells.Activeinvivo.

TechnicalData

M.Wt420.48
FormulaC20H22F2N4O2S.CF3CO2H
StorageStoreat-20°C
Purity≥98%(HPLC)
CASNumber885060-09-3
PubChemID90488964
InChIKeyCIJUJPVFECBUKG-BDQAORGHSA-N
SmilesFC1=CC=C(F)C=C1C2=NN(C(N(C)OC)=O)[C@](CCCN)([C@]3=CC=CC=C3)S2.FC(F)(F)C(O)=O

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO31.5475
ethanol31.5475

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight420.48.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM2.38mL11.89mL23.78mL
5mM0.48mL2.38mL4.76mL
10mM0.24mL1.19mL2.38mL
50mM0.05mL0.24mL0.48mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet