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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/AQ-RA 741/2292/10/10 mg
产品编号:2292/10
市  场 价:¥2980.00
场      地:美国(厂家直采)
产品分类: 生化试剂>生物分子>受体>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$149.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/AQ-RA 741/2292/10/10 mg
商品介绍
Description:Selective,highaffinityM2antagoNIST
ChemicalName:11-[[4-[4-(Diethylamino)butyl]-1-piperidinyl]acetyl]-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one
Purity:≥99%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Highaffinity,selectivemuscarinicM2receptorantagonist(pKivaluesare8.3,7.7and6.82forM2,M1andM3receptors,respectively).Displayscardioselectivityinvivo,overintestinal,trachealandbladdermuscarinicreceptors;inhibitsvagallyandagonist-inducedbradycardia.

CompoundLibraries

AQ-RA741isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt463.62
FormulaC27H37N5O2
StorageStoreatRT
Purity≥99%(HPLC)
CASNumber123548-16-3
PubChemID129989
InChIKeyBCUGCHZRMKTPMU-UHFFFAOYSA-N
SmilesCCN(CC)CCCCC1CCN(CC(=O)N2C3=CC=CC=C3C(=O)NC3=C2N=CC=C3)CC1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
1eq.HCl46.36100
DMSO46.36100
ethanol46.36100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight463.62.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM2.16mL10.78mL21.57mL
5mM0.43mL2.16mL4.31mL
10mM0.22mL1.08mL2.16mL
50mM0.04mL0.22mL0.43mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet