KITinhibitor;inhibitsphosphorylationofKIT,STAT3,STAT5andAkt.SuppressesproliferationofOCI/AML3cells(IC50=175nM).Caspase-dependantapoptosisinducer.
APcK110isalsoofferedaspartoftheTocriscreenPlusandTocriscreenKinaseInhibitorToolboxI.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
| M.Wt | 349.36 |
| Formula | C20H16FN3O2 |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 1001083-74-4 |
| PubChemID | 24786010 |
| InChIKey | CAMGZGMEPKFVMF-UHFFFAOYSA-N |
| Smiles | FC(C=C3)=CC=C3C1=NNC2=C1C=CC(C4=CC(OC)=CC(OC)=C4)=N2 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 34.94 | 100 |
Thefollowingdataisbasedontheproductmolecularweight349.36.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.86mL | 14.31mL | 28.62mL |
| 5mM | 0.57mL | 2.86mL | 5.72mL |
| 10mM | 0.29mL | 1.43mL | 2.86mL |
| 50mM | 0.06mL | 0.29mL | 0.57mL |



