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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/APETx2/4804/100U/100 ug
产品编号:4804/100U
市  场 价:¥6380.00
场      地:美国(厂家直采)
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$319.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/APETx2/4804/100U/100 ug
商品介绍
Description:ASIC3channelblocker
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Acid-sensingionchannel3(ASIC3)channelblocker(IC50valuesare63and175nMforhomomericratandhumanASIC3channels).AlsoinhibitsNaV1.8andNaV1.2channels(IC50valuesare55and114nMrespectively).Demonstratesanalgesicpropertiesagainstacid-inducedandinflammatorypain.

TechnicalData

M.Wt4561.06
FormulaC196H280N54O61S6
SequenceGTACSCGNSKGIYWFYRPSCPTDRGYTGSCRYFLGTCCTPAD

(Modifications:Disulfidebridgebetween4-37,6-30,20-38)

StorageStoreat-20°C
CASNumber713544-47-9
PubChemID90488973
InChIKeyHEHYILNFEUDIQC-UHFFFAOYSA-N
Smiles[H]NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C)C(=O)N[C@H]1CSSC[C@@H]2NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC3=CC=CC=C3)NC(=O)[C@H](CC3=CC=C(O)C=C3)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]3CSSC[C@H](NC(=O)[C@H](CO)NC1=O)C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CC1=CNC4=C1C=CC=C4)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CSSC[C@H](NC2=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CC(O)=O)C(O)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CO)C(=O)N3)[C@@H](C)O

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolubilitySolubleto5mg/mlinwater

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight4561.06.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM0.22mL1.1mL2.19mL
5mM0.04mL0.22mL0.44mL
10mM0.02mL0.11mL0.22mL
50mM0mL0.02mL0.04mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet