ReversibleTRPA1channelblocker(IC50valuesare3.1and4.5μMathumanandmouseTRPA1respectively).Blockscinnameldehyde-inducedbutnotcapsaicin-inducednociceptionandreversesmechanicalhyperalgesiainvivo.AlsoblocksTRPA1poredilation(IC50=10.3μMfortheinhibitionofYo-Prouptake).
AP18isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
| M.Wt | 209.67 |
| Formula | C11H12ClNO |
| Storage | Storeat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 55224-94-7 |
| PubChemID | 9584673 |
| InChIKey | MHTJEUOFLVQMCL-NJHPPEEMSA-N |
| Smiles | ClC1=CC=C(/C=C(C)/C(C)=N/O)C=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 20.97 | 100 | |
| ethanol | 20.97 | 100 |
Thefollowingdataisbasedontheproductmolecularweight209.67.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 4.77mL | 23.85mL | 47.69mL |
| 5mM | 0.95mL | 4.77mL | 9.54mL |
| 10mM | 0.48mL | 2.38mL | 4.77mL |
| 50mM | 0.1mL | 0.48mL | 0.95mL |



