AdenosineA2Areceptor(AA2AR)antagonist(Kivaluesare643and46nMforratandhumanAA2ARsrespectively).MostactiveAA2ARantagonistforhumanreceptors.DisplaysactivityinthetreatmentofParkinson'sdiseaseinvivo;improvesparkinsonianmotordeficitsandtremors.Exhibitsneuroprotectiveandanti-inflammatoryeffects.
ANR94isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
M.Wt | 207.23 |
Formula | C9H13N5O |
Storage | StoreatRT |
Purity | ≥99%(HPLC) |
CASNumber | 634924-89-3 |
PubChemID | 11805896 |
InChIKey | QUGDTMONBLMLLD-UHFFFAOYSA-N |
Smiles | CCN2C1=NC=NC(N)=C1N=C2OCC |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 10.36 | 50 | |
ethanol | 20.72 | 100 |
Thefollowingdataisbasedontheproductmolecularweight207.23.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 4.83mL | 24.13mL | 48.26mL |
5mM | 0.97mL | 4.83mL | 9.65mL |
10mM | 0.48mL | 2.41mL | 4.83mL |
50mM | 0.1mL | 0.48mL | 0.97mL |