Potentandselective,competitivevanilloidTRPV1receptorantagonist(IC50=17nM).Inhibitscapsaicin-,proton-,heat-andendogenousligand-inducedactivationofhumanandratrecombinantTRPV1receptors.Displaysantihyperalgesicpropertiesinaratmodelofinflammatorypain.
AMG9810isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
M.Wt | 337.42 |
Formula | C21H23NO3 |
Storage | Desiccateat+4°C |
Purity | ≥98%(HPLC) |
CASNumber | 545395-94-6 |
PubChemID | 680502 |
InChIKey | GZTFUVZVLYUPRG-IZZDOVSWSA-N |
Smiles | CC(C)(C)C1=CC=C(C=C1)C=CC(=O)NC1=CC=C2OCCOC2=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 16.87 | 50 | |
ethanol | 33.74 | 100 |
Thefollowingdataisbasedontheproductmolecularweight337.42.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.96mL | 14.82mL | 29.64mL |
5mM | 0.59mL | 2.96mL | 5.93mL |
10mM | 0.3mL | 1.48mL | 2.96mL |
50mM | 0.06mL | 0.3mL | 0.59mL |