请使用支持JavaScript的浏览器!
主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/AMG 853/5701/10/10 mg
产品编号:5701/10
市  场 价:¥5580.00
场      地:美国(厂家直采)
产品分类: 生化试剂>生物分子>受体>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$279.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/AMG 853/5701/10/10 mg
商品介绍
Description:PotentdualCRTH2andprostaglandinD2(PGD2)receptorantagoNIST
ChemicalName:5-Chloro-4-[2-[[(2-chloro-4-cyclopropylphenyl)sulfonyl]amino]-4-[[(1,1-dimethylethyl)amino]carbonyl]phenoxy]-2-fluorobenzeneaceticacid
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

PotentdualCRTH2andprostaglandinD2(PGD2)receptorantagonist(IC50valuesare8and35nM,respectivelyinplasma).InhibitsPGD2-induceddownmodulationofCRTH2onCD16-granulocytesinhumanwholebloodaswellasPGD2-inducedcAMPresponseinplatelets.InhibitsPGD2-inducedairwayconstrictioninvivo.AlsoinhibitsBRD4(Kd=170nM).Orallybioavailable.

TechnicalData

M.Wt609.49
FormulaC28H27Cl2FN2O6S
StorageStoreat-20°C
Purity≥98%(HPLC)
CASNumber1169483-24-2
PubChemID42641863
InChIKeyPFWVGKROPKKEDW-UHFFFAOYSA-N
SmilesClC1=CC(C2CC2)=CC=C1S(NC3=CC(C(NC(C)(C)C)=O)=CC=C3OC4=C(Cl)C=C(CC(O)=O)C(F)=C4)(=O)=O

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO60.95100
ethanol60.95100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight609.49.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM1.64mL8.2mL16.41mL
5mM0.33mL1.64mL3.28mL
10mM0.16mL0.82mL1.64mL
50mM0.03mL0.16mL0.33mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet