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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/AMG 21629/4330/1/1 mg
产品编号:4330/1
市  场 价:¥6900.00
场      地:美国(厂家直采)
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$345.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/AMG 21629/4330/1/1 mg
商品介绍
Description:PotentandselectiveTRPV1antagoNIST
ChemicalName:3-Amino-5-[[2-[(2-methoxyethyl)amino]-6-[4-(trifluoromethyl)phenyl]-4-pyrimidinyl]oxy]-2(1H)-quinoxalinone
Purity:≥97%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

PotentandselectiveTRPV1antagonist.BlocksCa2+uptakebyCHOcellsexpressingTRPV1receptors(IC50valuesare0.6and0.8nMforcapsaicin(Cat.No.0462)andacid-inducedCa2+uptake,respectively).Exhibits>4000-foldselectivityforTRPV1overotherTRPchannels.Blockscapsaicin-inducedflinchresponseandcauseshyperthermiainrats.Orallyavailableandnon-CNSpenetrant.

TechnicalData

M.Wt472.42
FormulaC22H19F3N6O3
StorageStoreat-20°C
Purity≥97%(HPLC)
CASNumber939040-79-6
PubChemID24858024
InChIKeyTUMYQRZCVIQKOQ-UHFFFAOYSA-N
SmilesNC(C(N4)=O)=NC(C4=CC=C3)=C3OC1=CC(C2=CC=C(C(F)(F)F)C=C2)=NC(NCCOC)=N1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO23.6250

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight472.42.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM2.12mL10.58mL21.17mL
5mM0.42mL2.12mL4.23mL
10mM0.21mL1.06mL2.12mL
50mM0.04mL0.21mL0.42mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet