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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/AMD 3100 octahydrochloride/3299/50/50 mg
产品编号:3299/50
市  场 价:¥11700.00
场      地:美国(厂家直采)
产品分类: 生化试剂>生物分子>受体>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$585.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/AMD 3100 octahydrochloride/3299/50/50 mg
商品介绍
Description:HighlyselectiveCXCR4antagoNIST
AlternativeNames:JM3100,Plerixafor
ChemicalName:1,1'-[1,4-Phenylenebis-(methylene)]-bis-(1,4,8,11-tetraazacyclotetradecane)octahydrochloride
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

HighlyselectiveCXCR4chemokinereceptorantagonist(IC50valuesare0.02-0.13and>25μMforCXCR4andallotherchemokinereceptorsrespectively).SwitchesinflammatoryresponsesfromTh4toTh1typeandreducesairwayhyperresponsivenessinamousemodelofasthma.PotentlyinhibitsHIV-1andHIV-2replicationinvitro(EC50=4-35nM)andmobilizeshematopoieticstemcellsinvivo.

TechnicalData

M.Wt794.48
FormulaC28H54N8.8HCl
StorageDesiccateat-20°C
CASNumber155148-31-5
PubChemID65014
InChIKeyUEUPDYPUTTUXLJ-UHFFFAOYSA-N
SmilesC1(CN3CCCNCCNCCCNCC3)=CC=C(CN2CCCNCCNCCCNCC2)C=C1.Cl.Cl.Cl.Cl.Cl.Cl.Cl.Cl

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
water79.45100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight794.48.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM1.26mL6.29mL12.59mL
5mM0.25mL1.26mL2.52mL
10mM0.13mL0.63mL1.26mL
50mM0.03mL0.13mL0.25mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet