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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/AM 80/3507/10/10 mg
产品编号:3507/10
市  场 价:¥3500.00
场      地:美国(厂家直采)
产品分类: 生化试剂>生物分子>受体>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$175.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/AM 80/3507/10/10 mg
商品介绍
Description:RARαagoNIST;anticancer
AlternativeNames:Tamibarotene
ChemicalName:4-[[(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)amino]carbonyl]benzoicacid
Purity:≥99%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Retinoicacidreceptorα(RARα)agonistthatinducesdifferentiation(ED50=0.79nM)andapoptosisofHL-60cellsinvitro.Exhibitsantiproliferativeeffectsagainstavarietyofhumantumorcellslines(meanvaluesof35,40and60%growthinhibitionat0.1,1and10μMrespectively)anddisplaysanticanceractivityagainstacutepromyelocyticleukemiainvivo.

TechnicalData

M.Wt351.44
FormulaC22H25NO3
StorageStoreatRT
Purity≥99%(HPLC)
CASNumber94497-51-5
PubChemID108143
InChIKeyMUTNCGKQJGXKEM-UHFFFAOYSA-N
SmilesO=C(C3=CC=C(C(O)=O)C=C3)NC(C=C2)=CC1=C2C(C)(C)CCC(C)1C

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
1.1eq.NaOH35.14100
DMSO17.5750
ethanol17.5750

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight351.44.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM2.85mL14.23mL28.45mL
5mM0.57mL2.85mL5.69mL
10mM0.28mL1.42mL2.85mL
50mM0.06mL0.28mL0.57mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet