Retinoicacidreceptorα(RARα)agonistthatinducesdifferentiation(ED50=0.79nM)andapoptosisofHL-60cellsinvitro.Exhibitsantiproliferativeeffectsagainstavarietyofhumantumorcellslines(meanvaluesof35,40and60%growthinhibitionat0.1,1and10μMrespectively)anddisplaysanticanceractivityagainstacutepromyelocyticleukemiainvivo.
M.Wt | 351.44 |
Formula | C22H25NO3 |
Storage | StoreatRT |
Purity | ≥99%(HPLC) |
CASNumber | 94497-51-5 |
PubChemID | 108143 |
InChIKey | MUTNCGKQJGXKEM-UHFFFAOYSA-N |
Smiles | O=C(C3=CC=C(C(O)=O)C=C3)NC(C=C2)=CC1=C2C(C)(C)CCC(C)1C |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
1.1eq.NaOH | 35.14 | 100 | |
DMSO | 17.57 | 50 | |
ethanol | 17.57 | 50 |
Thefollowingdataisbasedontheproductmolecularweight351.44.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.85mL | 14.23mL | 28.45mL |
5mM | 0.57mL | 2.85mL | 5.69mL |
10mM | 0.28mL | 1.42mL | 2.85mL |
50mM | 0.06mL | 0.28mL | 0.57mL |