PotentFFA1(GPR40)agonist(EC50=3.6nMinanIP3assayinGPR40transfectedA9cells).Inhibitsinsulinsecretionfromisolatedpancreaticislets.Reducesbloodglucoselevelsfollowingoralglucosechallengeinmice.Orallybioavailable.
| M.Wt | 488.48 |
| Formula | C24H19F3O4S |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 1011531-27-3 |
| PubChemID | 24897670 |
| InChIKey | BMLGZNVPWRUVNM-IBGZPJMESA-N |
| Smiles | CC1=C(COC2=CC=C(C=C2)[C@H](CC(O)=O)C2=NOC=C2)SC(=N1)C1=CC=C(C=C1)C(F)(F)F |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 48.85 | 100 | |
| ethanol | 48.85 | 100 |
Thefollowingdataisbasedontheproductmolecularweight488.48.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.05mL | 10.24mL | 20.47mL |
| 5mM | 0.41mL | 2.05mL | 4.09mL |
| 10mM | 0.2mL | 1.02mL | 2.05mL |
| 50mM | 0.04mL | 0.2mL | 0.41mL |



