PotentandselectiveTRPA1antagonist(IC50=0.02μMforhumanTRPA1).ExhibitsnosiginificantactivityagainsthumanTRPV1orTRPV4,andratTRPV1,TRPV3orTRPM8.Exhibitsefficacyinaratpainmodel.Orallybioavailable.
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Thefollowingdataisbasedontheproductmolecularweight370.79.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.