PotentandselectiveTRPA1antagonist(IC50=0.02μMforhumanTRPA1).ExhibitsnosiginificantactivityagainsthumanTRPV1orTRPV4,andratTRPV1,TRPV3orTRPM8.Exhibitsefficacyinaratpainmodel.Orallybioavailable.
| M.Wt | 370.79 |
| Formula | C17H15ClN6O2 |
| Storage | Storeat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 1883711-97-4 |
| PubChemID | 73297271 |
| InChIKey | AWJBWNUUODWOKQ-UHFFFAOYSA-N |
| Smiles | CN1C=NC2=C1C(N(C=N2)CC3=NC(CCC4=CC=C(C=C4)Cl)=NO3)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 37.08 | 100 |
Thefollowingdataisbasedontheproductmolecularweight370.79.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.7mL | 13.48mL | 26.97mL |
| 5mM | 0.54mL | 2.7mL | 5.39mL |
| 10mM | 0.27mL | 1.35mL | 2.7mL |
| 50mM | 0.05mL | 0.27mL | 0.54mL |



