PotentandselectiveTRPA1antagonist(IC50=0.02μMforhumanTRPA1).ExhibitsnosiginificantactivityagainsthumanTRPV1orTRPV4,andratTRPV1,TRPV3orTRPM8.Exhibitsefficacyinaratpainmodel.Orallybioavailable.
M.Wt | 370.79 |
Formula | C17H15ClN6O2 |
Storage | Storeat+4°C |
Purity | ≥98%(HPLC) |
CASNumber | 1883711-97-4 |
PubChemID | 73297271 |
InChIKey | AWJBWNUUODWOKQ-UHFFFAOYSA-N |
Smiles | CN1C=NC2=C1C(N(C=N2)CC3=NC(CCC4=CC=C(C=C4)Cl)=NO3)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 37.08 | 100 |
Thefollowingdataisbasedontheproductmolecularweight370.79.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.7mL | 13.48mL | 26.97mL |
5mM | 0.54mL | 2.7mL | 5.39mL |
10mM | 0.27mL | 1.35mL | 2.7mL |
50mM | 0.05mL | 0.27mL | 0.54mL |