SelectiveSIRT2inhibitor(IC50=15.5μM);displaysnoeffectonSIRT1orSIRT3.Decreasesneuronalcholesterollevels;improvesmotorfunctionandamelioratesbrainatrophyinamousemodelofHuntington'sdisease.Brainpenetrant.
AK7isalsoofferedaspartoftheTocriscreenPlusandTocriscreenEpigeneticsToolbox.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
M.Wt | 437.35 |
Formula | C19H21BrN2O3S |
Storage | Storeat+4°C |
Purity | ≥98%(HPLC) |
CASNumber | 420831-40-9 |
PubChemID | 1328033 |
InChIKey | IYAYHZZWYNXHEQ-UHFFFAOYSA-N |
Smiles | O=C(NC2=CC(Br)=CC=C2)C1=CC(S(N3CCCCCC3)(=O)=O)=CC=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 43.73 | 100 | |
ethanol | 4.37 | 10mMwithgentlewarming |
Thefollowingdataisbasedontheproductmolecularweight437.35.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.29mL | 11.43mL | 22.86mL |
5mM | 0.46mL | 2.29mL | 4.57mL |
10mM | 0.23mL | 1.14mL | 2.29mL |
50mM | 0.05mL | 0.23mL | 0.46mL |