SelectiveinhibitorofSIRT2(IC50=3.5μM).DisplaysnoactivityatSIRT1andSIRT3atconcentrationsupto40μM.Reducesα-synuclein-mediatedtoxicityininvitroandinvivomodelsofParkinson'sdisease.
| M.Wt | 434.27 |
| Formula | C23H13Cl2N3O2 |
| Storage | Storeat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 304896-28-4 |
| PubChemID | 2130404 |
| InChIKey | SVENPFFEMUOOGK-SDNWHVSQSA-N |
| Smiles | O=C(/C(C#N)=C/C3=CC=C(C4=C(Cl)C=CC(Cl)=C4)O3)NC2=CC=CC1=NC=CC=C12 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 4.34 | 10 |
Thefollowingdataisbasedontheproductmolecularweight434.27.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.3mL | 11.51mL | 23.03mL |
| 5mM | 0.46mL | 2.3mL | 4.61mL |
| 10mM | 0.23mL | 1.15mL | 2.3mL |
| 50mM | 0.05mL | 0.23mL | 0.46mL |



