SelectiveM2muscarinicreceptorantagonist.Kivaluesare64,417,786,211and5130nMforhumanrecombinantM2,M1,M3,M4andM5muscarinicreceptors,respectively.
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AF-DX116isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
| M.Wt | 421.54 |
| Formula | C24H31N5O2 |
| Storage | StoreatRT |
| Purity | ≥98%(HPLC) |
| CASNumber | 102394-31-0 |
| PubChemID | 107867 |
| InChIKey | UBRKDAVQCKZSPO-UHFFFAOYSA-N |
| Smiles | CCN(CC)CC1CCCCN1CC(=O)N1C2=C(C=CC=C2)C(=O)NC2=CC=CN=C12 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 10.54 | 25mMwithgentlewarming |
Thefollowingdataisbasedontheproductmolecularweight421.54.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.37mL | 11.86mL | 23.72mL |
| 5mM | 0.47mL | 2.37mL | 4.74mL |
| 10mM | 0.24mL | 1.19mL | 2.37mL |
| 50mM | 0.05mL | 0.24mL | 0.47mL |



