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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/AF 12198/1793/1/1 mg
产品编号:1793/1
市  场 价:¥6180.00
场      地:美国(厂家直采)
产品分类: 生化试剂>生物分子>受体>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$309.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/AF 12198/1793/1/1 mg
商品介绍
Description:Potent,selectivehumantypeIIL-1receptorantagoNIST
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

PotentandselectiveantagonistforthehumantypeIinterleukin-1(IL-1)receptor(IC50valuesare8nM,>6.7mMand>200mMforhumantypeI,humantypeIIandmurinetypeIIL-1receptorsrespectively).BlocksIL-1-inducedexpressionofICAM-1andE-selectininHUVECsandIL-1βinductionofIL-8inhumandermalfibroblasts.ReducesIL-1β-inducedIL-6productionandexhibitsanti-inflammatoryactivityinvivo.

TechnicalData

M.Wt1895.14
FormulaC96H123N19O22
SequenceFEWTPGWYQXYALPL

(Modifications:Phe-1=N-terminalAc,X-Aze,Leu-15=C-terminalamide)

StorageDesiccateat-20°C
CASNumber185413-30-3
PubChemID90488713
InChIKeyVASLMBMCJADVGR-BRPRRQPRSA-N
SmilesCC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)C1CCN1C(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC1=CC=C(O)C=C1)NC(=O)[C@H](CC1=CNC2=C1C=CC=C2)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](CC1=CNC2=C1C=CC=C2)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC1=CC=CC=C1)NC(C)=O)[C@@H](C)O)C(N)=O

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolubilitySolubleto1mg/mlin10%ethanol/PBS

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight1895.14.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM0.53mL2.64mL5.28mL
5mM0.11mL0.53mL1.06mL
10mM0.05mL0.26mL0.53mL
50mM0.01mL0.05mL0.11mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet