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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/ADWX 1/4812/100U/100 ug
产品编号:4812/100U
市  场 价:¥6380.00
场      地:美国(厂家直采)
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$319.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/ADWX 1/4812/100U/100 ug
商品介绍
Description:PotentandselectiveKV1.3channelblocker
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

PotentandselectiveKV1.3channelblocker(IC50valuesare0.0019and0.65nMforKV1.3andKV1.1,respectively).InhibitsCD4+CCR7-Tcellactivation.Amelioratesratexperimentalautoimmuneencephalomyelitis,inamodelformultiplesclerosis.

TechnicalData

M.Wt4071.86
FormulaC169H281N57O46S7
SequenceVGINVKCKHSRQCLKPCKDAGMRFGKCTNGKCHCTPK

(Modifications:Disulfidebridge:7-27,13-32,17-34)

StorageStoreat-20°C
PubChemID90488974
InChIKeyKOXLLJFKLFSCAF-UHFFFAOYSA-N
Smiles[H]NC(C(C)C)C(=O)NCC(=O)NC(C(C)CC)C(=O)NC(CC(N)=O)C(=O)NC(C(C)C)C(=O)NC(CCCCN)C(=O)NC1CSSCC2NC(=O)C(CCCCN)NC(=O)CNC(=O)C(CC3=CC=CC=C3)NC(=O)C(CCCNC(N)=N)NC(=O)C(CCSC)NC(=O)CNC(=O)C(C)NC(=O)C(CC(O)=O)NC(=O)C(CCCCN)NC(=O)C3CSSCC(NC(=O)C(CC4=CNC=N4)NC(=O)C(CSSCC(NC(=O)C(CCC(N)=O)NC(=O)C(CCCNC(N)=N)NC(=O)C(CO)NC(=O)C(CC4=CNC=N4)NC(=O)C(CCCCN)NC1=O)C(=O)NC(CC(C)C)C(=O)NC(CCCCN)C(=O)N1CCCC1C(=O)N3)NC(=O)C(CCCCN)NC(=O)CNC(=O)C(CC(N)=O)NC(=O)C(NC2=O)C(C)O)C(=O)NC(C(C)O)C(=O)N1CCCC1C(=O)NC(CCCCN)C(O)=O

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolubilitySolubleto2mg/mlinwater

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight4071.86.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM0.25mL1.23mL2.46mL
5mM0.05mL0.25mL0.49mL
10mM0.02mL0.12mL0.25mL
50mM0mL0.02mL0.05mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet