PotentandselectiveKV1.3channelblocker(IC50valuesare0.0019and0.65nMforKV1.3andKV1.1,respectively).InhibitsCD4+CCR7-Tcellactivation.Amelioratesratexperimentalautoimmuneencephalomyelitis,inamodelformultiplesclerosis.
M.Wt | 4071.86 |
Formula | C169H281N57O46S7 |
Sequence | VGINVKCKHSRQCLKPCKDAGMRFGKCTNGKCHCTPK (Modifications:Disulfidebridge:7-27,13-32,17-34) |
Storage | Storeat-20°C |
PubChemID | 90488974 |
InChIKey | KOXLLJFKLFSCAF-UHFFFAOYSA-N |
Smiles | [H]NC(C(C)C)C(=O)NCC(=O)NC(C(C)CC)C(=O)NC(CC(N)=O)C(=O)NC(C(C)C)C(=O)NC(CCCCN)C(=O)NC1CSSCC2NC(=O)C(CCCCN)NC(=O)CNC(=O)C(CC3=CC=CC=C3)NC(=O)C(CCCNC(N)=N)NC(=O)C(CCSC)NC(=O)CNC(=O)C(C)NC(=O)C(CC(O)=O)NC(=O)C(CCCCN)NC(=O)C3CSSCC(NC(=O)C(CC4=CNC=N4)NC(=O)C(CSSCC(NC(=O)C(CCC(N)=O)NC(=O)C(CCCNC(N)=N)NC(=O)C(CO)NC(=O)C(CC4=CNC=N4)NC(=O)C(CCCCN)NC1=O)C(=O)NC(CC(C)C)C(=O)NC(CCCCN)C(=O)N1CCCC1C(=O)N3)NC(=O)C(CCCCN)NC(=O)CNC(=O)C(CC(N)=O)NC(=O)C(NC2=O)C(C)O)C(=O)NC(C(C)O)C(=O)N1CCCC1C(=O)NC(CCCCN)C(O)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solubility | Solubleto2mg/mlinwater |
Thefollowingdataisbasedontheproductmolecularweight4071.86.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 0.25mL | 1.23mL | 2.46mL |
5mM | 0.05mL | 0.25mL | 0.49mL |
10mM | 0.02mL | 0.12mL | 0.25mL |
50mM | 0mL | 0.02mL | 0.05mL |