Ligandoftranslocatorprotein(TSPO,peripheralbenzodiazepinereceptor).ExhibitshighaffinityforTSPOinratwholebrain(Ki=0.297nM),andhighpotencyagainsthumanandratglialTSPO(IC50valuesare2.73and3.04nMrespectively).Displaysnonoticeablebindingtoanumberofotherreceptors,transportersorionchannels.Alsodisplaysanxiolyticandantidepressanteffectsinrodentmodels,withoutinducingbenzodiazepine-likeadverseeffects.
AC5216isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
M.Wt | 401.46 |
Formula | C23H23N5O2 |
Storage | Storeat+4°C |
Purity | ≥98%(HPLC) |
CASNumber | 226954-04-7 |
PubChemID | 6433109 |
InChIKey | NBMBIEOUVBHEBM-UHFFFAOYSA-N |
Smiles | O=C(N1C)N(CC(N(CC)CC2=CC=CC=C2)=O)C3=C1C=NC(C4=CC=CC=C4)=N3 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 40.15 | 100 | |
ethanol | 4.01 | 10mMwithsonication |
Thefollowingdataisbasedontheproductmolecularweight401.46.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.49mL | 12.45mL | 24.91mL |
5mM | 0.5mL | 2.49mL | 4.98mL |
10mM | 0.25mL | 1.25mL | 2.49mL |
50mM | 0.05mL | 0.25mL | 0.5mL |