Antimitoticagent,inhibitsmicrotubulepolymerization.Bindstoβ-tubulinonthecolchinesite;blockscellcycleatG2Mphaseandinducesapoptosis.Exhibitsantitumoractivity.Alsodisplaysactivityincelllinesresistanttovincristine,doxorubicinandcisplatin.Orallybioavailable.
ABT751isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
M.Wt | 371.41 |
Formula | C18H17N3O4S |
Storage | Storeat+4°C |
Purity | ≥98%(HPLC) |
CASNumber | 141430-65-1 |
PubChemID | 3035714 |
InChIKey | URCVCIZFVQDVPM-UHFFFAOYSA-N |
Smiles | OC(C=C2)=CC=C2NC1=NC=CC=C1NS(C3=CC=C(OC)C=C3)(=O)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 37.14 | 100 | |
ethanol | 9.29 | 25 |
Thefollowingdataisbasedontheproductmolecularweight371.41.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.69mL | 13.46mL | 26.92mL |
5mM | 0.54mL | 2.69mL | 5.38mL |
10mM | 0.27mL | 1.35mL | 2.69mL |
50mM | 0.05mL | 0.27mL | 0.54mL |