Antimitoticagent,inhibitsmicrotubulepolymerization.Bindstoβ-tubulinonthecolchinesite;blockscellcycleatG2Mphaseandinducesapoptosis.Exhibitsantitumoractivity.Alsodisplaysactivityincelllinesresistanttovincristine,doxorubicinandcisplatin.Orallybioavailable.
ABT751isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
| M.Wt | 371.41 |
| Formula | C18H17N3O4S |
| Storage | Storeat+4°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 141430-65-1 |
| PubChemID | 3035714 |
| InChIKey | URCVCIZFVQDVPM-UHFFFAOYSA-N |
| Smiles | OC(C=C2)=CC=C2NC1=NC=CC=C1NS(C3=CC=C(OC)C=C3)(=O)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 37.14 | 100 | |
| ethanol | 9.29 | 25 |
Thefollowingdataisbasedontheproductmolecularweight371.41.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.69mL | 13.46mL | 26.92mL |
| 5mM | 0.54mL | 2.69mL | 5.38mL |
| 10mM | 0.27mL | 1.35mL | 2.69mL |
| 50mM | 0.05mL | 0.27mL | 0.54mL |



