PotentdopamineD4receptorpartialagonist(EC50=12.4nM;61%efficacyvs.dopamine).HasnoagonistactivityatD2receptors(EC50>10μM).Selectiveinratsinvivo;producespenileerectionfollowingi.c.v.administration;increasesintracavernosalpressureandpotentiatestheproerectileeffectsofsildenafilfollowings.c.administration.Displaysminimalsideeffects.
M.Wt | 402.75 |
Formula | C17H19N5.3HCl |
Storage | Desiccateat+4°C |
Purity | ≥99%(HPLC) |
CASNumber | 587870-77-7 |
PubChemID | 16759165 |
InChIKey | AZFUVPBLKQGSRI-UHFFFAOYSA-N |
Smiles | Cl.Cl.Cl.C(N1CCN(CC1)C1=NC=CC=C1)C1=NC2=CC=CC=C2N1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
water | 40.27 | 100 |
Thefollowingdataisbasedontheproductmolecularweight402.75.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.48mL | 12.41mL | 24.83mL |
5mM | 0.5mL | 2.48mL | 4.97mL |
10mM | 0.25mL | 1.24mL | 2.48mL |
50mM | 0.05mL | 0.25mL | 0.5mL |