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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/17-AAG/1515/1/1 mg
产品编号:1515/1
市  场 价:¥3300.00
场      地:美国(厂家直采)
产品分类: 蛋白类>天然蛋白>白蛋白>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$165.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/17-AAG/1515/1/1 mg
商品介绍
Description:SelectiveHsp90inhibitor
AlternativeNames:NSC330507,17-(Allylamino)-17-demethoxygeldanamycin,Tanespimycin
ChemicalName:17-Demethoxy-17-(2-propenylamino)geldanamycin
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Inhibitorofheatshockprotein90(Hsp90)chaperoneactivity,andananalogofgeldanamycin(Cat.No.1368).Subsequentlyinhibitstheactivityofoncogenicproteinssuchasp185erbB-2(IC50=31nM),N-ras,Ki-rasandc-Akt.Antitumorinvivo.AlsoprotectsneuroProgenitorcellsagainststress-inducedapoptosisatlowconcentrations(10nM)invitro.

TechnicalData

M.Wt585.7
FormulaC31H43N3O8
StorageDesiccateat-20°C
Purity≥98%(HPLC)
CASNumber75747-14-7
PubChemID6440175
InChIKeyAYUNIORJHRXIBJ-HTLBVUBBSA-N
SmilesO=C1C(NCC=C)=C(C[C@@H](C)C[C@H](OC)[C@H](O)[C@@H](C)/C=C(C)/[C@H](OC(N)=O)[C@@H](OC)/C=C/C=C(C)/C2=O)C(C(N2)=C1)=O

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO58.57100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight585.7.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM1.71mL8.54mL17.07mL
5mM0.34mL1.71mL3.41mL
10mM0.17mL0.85mL1.71mL
50mM0.03mL0.17mL0.34mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet