Potentstearoyl-CoAdesaturase1(SCD1)inhibitor(IC50=0.4nM).SelectiveforSCD1overarangeofkinasesandhERGchannels.InhibitsproliferationofsquamouscellcarcinomaFaDucellsinvitro.Alsoinducescelldeathofundifferentiatedhumanembryonicstemcells(ESCs).Orallybioavailable.
A939572isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
M.Wt | 387.86 |
Formula | C20H22ClN3O3 |
Storage | Storeat+4°C |
Purity | ≥99%(HPLC) |
CASNumber | 1032229-3-6 |
PubChemID | 24905400 |
InChIKey | DPYTYQFYDLYWHZ-UHFFFAOYSA-N |
Smiles | O=C(NC3=CC(C(NC)=O)=CC=C3)N1CCC(OC2=C(Cl)C=CC=C2)CC1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 38.79 | 100 | |
ethanol | 3.88 | 10mMwithgentlewarming |
Thefollowingdataisbasedontheproductmolecularweight387.86.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.58mL | 12.89mL | 25.78mL |
5mM | 0.52mL | 2.58mL | 5.16mL |
10mM | 0.26mL | 1.29mL | 2.58mL |
50mM | 0.05mL | 0.26mL | 0.52mL |