Diacylglycerolacyltransferase1(DGAT-1)inhibitor(IC50valuesare7and24nMathumanandmouseDGAT-1respectively)thatisdevoidofactivityatDGAT-2,ACAT1orACAT2.Inducessignificantweightlosswithoutalteringfoodintake,anddecreasesliverandplasmatriglyceridelevelsinvivo.Orallyactive.
A922500isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
M.Wt | 428.48 |
Formula | C26H24N2O4 |
Storage | Desiccateat+4°C |
Purity | ≥98%(HPLC) |
CASNumber | 959122-11-3 |
PubChemID | 24768261 |
InChIKey | BOZRFEQDOFSZBV-DHIUTWEWSA-N |
Smiles | O=[C@]([C@@H]3CCC[C@H]3[C@@](O)=O)C(C=C2)=CC=C2C1=CC=C(NC(NC4=CC=CC=C4)=O)C=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 21.42 | 50 |
Thefollowingdataisbasedontheproductmolecularweight428.48.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.33mL | 11.67mL | 23.34mL |
5mM | 0.47mL | 2.33mL | 4.67mL |
10mM | 0.23mL | 1.17mL | 2.33mL |
50mM | 0.05mL | 0.23mL | 0.47mL |