PotentTRPV1antagonist(IC50=25nMforinhibitionofTRPV1activationby50nMcapsaicin).Displaysnoactivityagainstarangeofreceptors,includingTRPA1,GABA,opioid,andpurinergicreceptors.
A784168isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
| M.Wt | 479.4 |
| Formula | C19H15F6N3O3S |
| Storage | StoreatRT |
| Purity | ≥99%(HPLC) |
| CASNumber | 824982-41-4 |
| PubChemID | 11420211 |
| InChIKey | SDUAWRFBHRAFBM-UHFFFAOYSA-N |
| Smiles | O=C(NC3=CC=C(S(=O)(C(F)(F)F)=O)C=C3)C(CC2)=CCN2C1=C(C(F)(F)F)C=CC=N1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 47.94 | 100 | |
| ethanol | 23.97 | 50 |
Thefollowingdataisbasedontheproductmolecularweight479.4.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.09mL | 10.43mL | 20.86mL |
| 5mM | 0.42mL | 2.09mL | 4.17mL |
| 10mM | 0.21mL | 1.04mL | 2.09mL |
| 50mM | 0.04mL | 0.21mL | 0.42mL |



