PotentTRPV1antagonist(IC50=25nMforinhibitionofTRPV1activationby50nMcapsaicin).Displaysnoactivityagainstarangeofreceptors,includingTRPA1,GABA,opioid,andpurinergicreceptors.
A784168isalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
M.Wt | 479.4 |
Formula | C19H15F6N3O3S |
Storage | StoreatRT |
Purity | ≥99%(HPLC) |
CASNumber | 824982-41-4 |
PubChemID | 11420211 |
InChIKey | SDUAWRFBHRAFBM-UHFFFAOYSA-N |
Smiles | O=C(NC3=CC=C(S(=O)(C(F)(F)F)=O)C=C3)C(CC2)=CCN2C1=C(C(F)(F)F)C=CC=N1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 47.94 | 100 | |
ethanol | 23.97 | 50 |
Thefollowingdataisbasedontheproductmolecularweight479.4.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.09mL | 10.43mL | 20.86mL |
5mM | 0.42mL | 2.09mL | 4.17mL |
10mM | 0.21mL | 1.04mL | 2.09mL |
50mM | 0.04mL | 0.21mL | 0.42mL |