SelectiveagonistforthedopamineD4receptor(Kivaluesare7.9and12.1nMforhumanD4andratD4receptors).Displaysnoaffinity(<1000nM)forotherdopaminereceptors.ShowsefficacyinratmodelsofADHDandshort-termmemory.
A412997dihydrochlorideisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
M.Wt | 382.33 |
Formula | C19H23N3O.2HCl |
Storage | DesiccateatRT |
Purity | ≥98%(HPLC) |
CASNumber | 1347744-96-0 |
PubChemID | 90488953 |
InChIKey | KIGNSSHMCNBHQX-UHFFFAOYSA-N |
Smiles | O=C(CN2CCC(C3=CC=CC=N3)CC2)NC1=CC=CC(C)=C1.Cl.Cl |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 19.12 | 50 | |
ethanol | 1.91 | 5 | |
water | 38.23 | 100 |
Thefollowingdataisbasedontheproductmolecularweight382.33.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.62mL | 13.08mL | 26.16mL |
5mM | 0.52mL | 2.62mL | 5.23mL |
10mM | 0.26mL | 1.31mL | 2.62mL |
50mM | 0.05mL | 0.26mL | 0.52mL |