IRE-1RNaseinhibitor(IC50=1.23μM).InhibitsIRE-1/XBP1pathway.Cellpermeable.Inhibitsgrowthofhumanchroniclymphocyticleukemia(CLL)cellsinvitroandpromotesCLLregressioninamousemodel.
| M.Wt | 303.31 |
| Formula | C16H17NO5 |
| Storage | Storeat-20°C |
| Purity | ≥98%(HPLC) |
| CASNumber | 1607803-67-7 |
| PubChemID | 86290458 |
| InChIKey | UYYMWNUDIOPESF-UHFFFAOYSA-N |
| Smiles | OC1=CC=C2C3=C(C(OC2=C1C4OCCCO4)=O)CNCC3 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 15.17 | 50 |
Thefollowingdataisbasedontheproductmolecularweight303.31.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 3.3mL | 16.48mL | 32.97mL |
| 5mM | 0.66mL | 3.3mL | 6.59mL |
| 10mM | 0.33mL | 1.65mL | 3.3mL |
| 50mM | 0.07mL | 0.33mL | 0.66mL |



