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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/LDN 214117/6152/50/50 mg
产品编号:6152/50
市  场 价:¥15900.00
场      地:美国(厂家直采)
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$795.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/LDN 214117/6152/50/50 mg
商品介绍
Description:PotentandselectiveALK2inhibitor
ChemicalName:1-[4-[6-Methyl-5-(3,4,5-trimethoxyphenyl)-3-pyridinyl]phenyl]piperazine
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

PotentandselectiveinhibitoroftypeIbonemorphogenicprotein(BMP)receptorALK2(IC50=24nM).ShowspreferenceforALK1andALK2overALK3and164-foldselectivityforBMP6inhibition(IC50=100nM)overTGF-β1.ExhibitsimprovedkinomeselectivityoverK02288(Cat.No.4986)andlowcytotoxicity.

LicensingInformation

SoldforresearchpurposesunderexclusiveagreementfromTheBrighamandWomen"sHospitalInc.USpatent14/776,302

TechnicalData

M.Wt419.52
FormulaC25H29N3O3
StorageStoreat-20°C
Purity≥98%(HPLC)
CASNumber1627503-67-6
PubChemID91754554
InChIKeyBHUXVRVMMYAXKN-UHFFFAOYSA-N
SmilesCOC1=CC(C2=C(N=CC(C3=CC=C(N4CCNCC4)C=C3)=C2)C)=CC(OC)=C1OC

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO41.95100
ethanol41.95100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight419.52.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM2.38mL11.92mL23.84mL
5mM0.48mL2.38mL4.77mL
10mM0.24mL1.19mL2.38mL
50mM0.05mL0.24mL0.48mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet