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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/AZD 2461/6060/50/50 mg
产品编号:6060/50
市  场 价:¥9700.00
场      地:美国(厂家直采)
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$485.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/AZD 2461/6060/50/50 mg
商品介绍
Description:PotentPARPinhibitor;orallybioavailable
ChemicalName:4-[[4-Fluoro-3-[(4-methoxy-1-piperidinyl)carbonyl]phenyl]methyl]-1(2H)-phthalazinone
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

PotentPARPinhibitor(IC50valuesare2,5and200nMforPARP2,PARP1andPARP3,respectively).ExhibitsanticancereffectsinBRCA1mutant,butnotwild-typebreastcancercelllinesinvitro.Inhibitsgrowthofolaparib-resistantmammarytumorsinamousemodelandisapoorsubstratefortheP-gptransporter.Orallybioavailable.

TechnicalData

M.Wt395.43
FormulaC22H22FN3O3
StorageStoreat-20°C
Purity≥98%(HPLC)
CASNumber1174043-16-3
PubChemID44199317
InChIKeyHYNBNUYQTQIHJK-UHFFFAOYSA-N
SmilesCOC1CCN(C(C2=C(C=CC(CC3=NNC(C4=CC=CC=C34)=O)=C2)F)=O)CC1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO39.54100
ethanol39.54100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight395.43.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM2.53mL12.64mL25.29mL
5mM0.51mL2.53mL5.06mL
10mM0.25mL1.26mL2.53mL
50mM0.05mL0.25mL0.51mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet