PotentandhighlyselectivePDE5inhibitor(IC50=5nM).Exhibits>2000-foldselectivityforPDE5overPDEs1,2,3and4and1000-foldselectivityoverPDE6.Reducesbloodpressureinhypertensiverats.AlsodelaystumorgrowthinamousemodelviainhibitionofMDSC-mediatedimmunosuppression.Orallybioavailable.
| M.Wt | 389.4 |
| Formula | C22H19N3O4 |
| Storage | Storeat-20°C |
| Purity | ≥99%(HPLC) |
| CASNumber | 171596-29-5 |
| PubChemID | 110635 |
| InChIKey | WOXKDUGGOYFFRN-IIBYNOLFSA-N |
| Smiles | [H][C@]12CC3=C([C@@H](C4=CC5=C(C=C4)OCO5)N1C(CN(C2=O)C)=O)NC6=CC=CC=C36 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 38.94 | 100 |
Thefollowingdataisbasedontheproductmolecularweight389.4.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.57mL | 12.84mL | 25.68mL |
| 5mM | 0.51mL | 2.57mL | 5.14mL |
| 10mM | 0.26mL | 1.28mL | 2.57mL |
| 50mM | 0.05mL | 0.26mL | 0.51mL |



