PotentandhighlyselectivePDE5inhibitor(IC50=5nM).Exhibits>2000-foldselectivityforPDE5overPDEs1,2,3and4and1000-foldselectivityoverPDE6.Reducesbloodpressureinhypertensiverats.AlsodelaystumorgrowthinamousemodelviainhibitionofMDSC-mediatedimmunosuppression.Orallybioavailable.
M.Wt | 389.4 |
Formula | C22H19N3O4 |
Storage | Storeat-20°C |
Purity | ≥99%(HPLC) |
CASNumber | 171596-29-5 |
PubChemID | 110635 |
InChIKey | WOXKDUGGOYFFRN-IIBYNOLFSA-N |
Smiles | [H][C@]12CC3=C([C@@H](C4=CC5=C(C=C4)OCO5)N1C(CN(C2=O)C)=O)NC6=CC=CC=C36 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 38.94 | 100 |
Thefollowingdataisbasedontheproductmolecularweight389.4.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.57mL | 12.84mL | 25.68mL |
5mM | 0.51mL | 2.57mL | 5.14mL |
10mM | 0.26mL | 1.28mL | 2.57mL |
50mM | 0.05mL | 0.26mL | 0.51mL |