BETbromodomaininhibitor(IC50valuesareintherange92-112nM).Inhibitsproliferationandinducesapoptosisofleukemiacelllinesinvitro.DecreasesBRD2,BRD4andc-MYCproteinexpression.Orallybioavailable.
M.Wt | 491.99 |
Formula | C25H22ClN5O2S |
Storage | Storeat-20°C |
Purity | ≥98%(HPLC) |
CASNumber | 202590-98-5 |
PubChemID | 9936746 |
InChIKey | GNMUEVRJHCWKTO-FQEVSTJZSA-N |
Smiles | CC1=C(C2=C(N3C(C)=NN=C3[C@@H](N=C2C4=CC=C(C=C4)Cl)CC(NC5=CC=C(C=C5)O)=O)S1)C |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 49.2 | 100 | |
ethanol | 9.84 | 20 |
Thefollowingdataisbasedontheproductmolecularweight491.99.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.03mL | 10.16mL | 20.33mL |
5mM | 0.41mL | 2.03mL | 4.07mL |
10mM | 0.2mL | 1.02mL | 2.03mL |
50mM | 0.04mL | 0.2mL | 0.41mL |