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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/MS 275/6208/50/50 mg
产品编号:6208/50
市  场 价:¥10500.00
场      地:美国(厂家直采)
产品分类: 蛋白类>>其它酶>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$525.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/MS 275/6208/50/50 mg
商品介绍
Description:HDAC(ClassI)inhibitor
AlternativeNames:entinostat,SNDX275
ChemicalName:(Pyridin-3-yl)methyl4-(2-aminophenylcarbamoyl)benzylcarbamate
Purity:≥99%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

ClassIHDACinhibitor(IC50valuesare0.18,0.74,44.9and>100μMforHDAC1,3,8and6,respectively).Exhibitsantiproliferativeeffectsandinducesapoptosisinarangeoftumorcelllinesinvitroandinvivo.Increasesestrogenreceptorα-andaromataseexpressioninbreastcancercells.InhibitsPCB-inducedneuronalcelldeathbypreventingHDAC3bindingandhistonedeacetylationwithinthesynapsin-1promoter.

TechnicalData

M.Wt376.41
FormulaC21H20N4O3
StorageStoreat-20°C
Purity≥99%(HPLC)
CASNumber209783-80-2
PubChemID4261
InChIKeyINVTYAOGFAGBOE-UHFFFAOYSA-N
SmilesO=C(C1=CC=C(C=C1)CNC(OCC2=CN=CC=C2)=O)NC3=CC=CC=C3N

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO37.64100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight376.41.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM2.66mL13.28mL26.57mL
5mM0.53mL2.66mL5.31mL
10mM0.27mL1.33mL2.66mL
50mM0.05mL0.27mL0.53mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet