G9ainhibitorandS-adenosylmethionine(SAM)mimetic.InhibitsmethylationofH3K9(EC50~5μM)andinducessenescenceinPANC-1cells.InducesATMactivationwithoutDNAdamage.Cellpermeable.
M.Wt | 413.47 |
Formula | C25H23N3O3 |
Storage | Storeat+4°C |
Purity | ≥98%(HPLC) |
CASNumber | 1374601-40-7 |
PubChemID | 72193870 |
InChIKey | UCGWYCMPZXDHNR-UHFFFAOYSA-N |
Smiles | COC(C1=CC=C2N(C(NC(C3=CC=CC=C3)=O)=NC2=C1)CCCC4=CC=CC=C4)=O |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 8.27 | 20 |
Thefollowingdataisbasedontheproductmolecularweight413.47.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.42mL | 12.09mL | 24.19mL |
5mM | 0.48mL | 2.42mL | 4.84mL |
10mM | 0.24mL | 1.21mL | 2.42mL |
50mM | 0.05mL | 0.24mL | 0.48mL |