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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/Zosuquidar trihydrochloride/5456/10/10 mg
产品编号:5456/10
市  场 价:¥3700.00
场      地:美国(厂家直采)
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$185.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/Zosuquidar trihydrochloride/5456/10/10 mg
商品介绍
Description:HighaffinityP-gpinhibitor
AlternativeNames:LY335979
ChemicalName:(αR)-4-[(1aα,6α,10bα)-1,1-Difluoro-1,1a,6,10b-tetrahydrodibenzo[a,e]cyclopropa[c]cyclohepten-6-yl]-α-[(5-quinolinyloxy)methyl]-1-piperazineethanoltrihydrochloride
Purity:≥98%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

HighaffinityP-glycoprotein(P-gp)inhibitor(Kd=79nM).Restoresdoxorubicin(Cat.No.2252)sensitivityinP-gp-expressingmultidrug(MDR)resistantcancercelllines.Alsopotentiatesantitumorefficacyoftaxol(Cat.No.1097)inaMDRhumannon-smallcelllungcarcinomaxenograftmousemodel.

CompoundLibraries

ZosuquidartrihydrochlorideisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt636.99
FormulaC32H31F2N3O2.3HCl
StorageStoreat-20°C
Purity≥98%(HPLC)
CASNumber167465-36-3
PubChemID153997
InChIKeyZPFVQKPWGDRLHL-ZLYBXYBFSA-N
SmilesF[C@@]2(F)[C@H]1C3=C(C=CC=C3)[C@H](N5CCN(C[C@H](COC6=CC=CC7=C6C=CC=N7)O)CC5)C4=C(C=CC=C4)[C@H]12.Cl.Cl.Cl

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO31.8550

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight636.99.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM1.57mL7.85mL15.7mL
5mM0.31mL1.57mL3.14mL
10mM0.16mL0.78mL1.57mL
50mM0.03mL0.16mL0.31mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet