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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/Zoniporide dihydrochloride/2727/10/10 mg
产品编号:2727/10
市  场 价:¥3980.00
场      地:美国(厂家直采)
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$199.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/Zoniporide dihydrochloride/2727/10/10 mg
商品介绍
Description:SelectiveNHE1inhibitor
AlternativeNames:CP597396
ChemicalName:[1-(Quinolin-5-yl)-5-cyclopropyl-1H-pyrazole-4-carbonyl]guanidinedihydrochloride
Purity:≥99%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Sodium-hydrogenexchangerisoform1(NHE1)inhibitorthatdisplaysselectivityoverotherNHEisoforms(Kivaluesare14,2200and220000nMforhumanNHE1,humanNHE2andratNHE3respectively).InhibitsNHE1dependent22Na+uptakeinvitro(IC50=14nM)andprovidescardioprotectionfrommyocardialischemicinjuryinvivo(EC50=0.25nM).AlsoinhibitsMMP2/9activityandinvasioninbreastcancercells.

LicensingInformation

SoldforresearchpurposesunderagreementfromPfizerInc

CompoundLibraries

ZoniporidedihydrochlorideisalsoofferedaspartoftheTocriscreenPlus.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt393.27
FormulaC17H16N6O.2HCl
StorageStoreat-20°C
Purity≥99%(HPLC)
CASNumber241799-10-0
PubChemID22267855
InChIKeyARZNPJAGKWHEHT-UHFFFAOYSA-N
SmilesO=C(/N=C(N)/N)C(C=N3)=C(C4CC4)N3C1=C2C(N=CC=C2)=CC=C1.Cl.Cl

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO39.33100
water3.9310

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight393.27.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM2.54mL12.71mL25.43mL
5mM0.51mL2.54mL5.09mL
10mM0.25mL1.27mL2.54mL
50mM0.05mL0.25mL0.51mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet