Orallyactive5-lipoxygenase(5-LOX)inhibitorthatinhibitsLTB4synthesis(IC50valuesare0.56,2.3and2.6μMindog,ratandhumanbloodrespectively).Inhibitsantigen-inducedcontractionoftrachealstripsinvitro(IC50=6μM)andexhibitsantiasthmaticactivityinvivo.AlsoweaklyinhibitsCYP1A2(Ki=66-98μM).
ZileutonisalsoofferedaspartoftheTocriscreenPlusandTocriscreenLibraryofFDA-ApprovedCompounds.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
M.Wt | 236.29 |
Formula | C11H12N2O2S |
Storage | Storeat+4°C |
Purity | ≥99%(HPLC) |
CASNumber | 111406-87-2 |
PubChemID | 60490 |
InChIKey | MWLSOWXNZPKENC-UHFFFAOYSA-N |
Smiles | CC(N(O)C(N)=O)C2=CC1=CC=CC=C1S2 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 23.63 | 100 |
Thefollowingdataisbasedontheproductmolecularweight236.29.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 4.23mL | 21.16mL | 42.32mL |
5mM | 0.85mL | 4.23mL | 8.46mL |
10mM | 0.42mL | 2.12mL | 4.23mL |
50mM | 0.08mL | 0.42mL | 0.85mL |