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主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/Zileuton/3308/10/10 mg
产品编号:3308/10
市  场 价:¥1300.00
场      地:美国(厂家直采)
产品分类: 蛋白类>>其它酶>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$65.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/Zileuton/3308/10/10 mg
商品介绍
Description:5-LOXinhibitor;orallybioavailable
AlternativeNames:ICID2138
ChemicalName:N-(1-Benzo[b]thien-2-ylethyl)-N-hydroxyurea
Purity:≥99%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Orallyactive5-lipoxygenase(5-LOX)inhibitorthatinhibitsLTB4synthesis(IC50valuesare0.56,2.3and2.6μMindog,ratandhumanbloodrespectively).Inhibitsantigen-inducedcontractionoftrachealstripsinvitro(IC50=6μM)andexhibitsantiasthmaticactivityinvivo.AlsoweaklyinhibitsCYP1A2(Ki=66-98μM).

CompoundLibraries

ZileutonisalsoofferedaspartoftheTocriscreenPlusandTocriscreenLibraryofFDA-ApprovedCompounds.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt236.29
FormulaC11H12N2O2S
StorageStoreat+4°C
Purity≥99%(HPLC)
CASNumber111406-87-2
PubChemID60490
InChIKeyMWLSOWXNZPKENC-UHFFFAOYSA-N
SmilesCC(N(O)C(N)=O)C2=CC1=CC=CC=C1S2

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO23.63100

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight236.29.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM4.23mL21.16mL42.32mL
5mM0.85mL4.23mL8.46mL
10mM0.42mL2.12mL4.23mL
50mM0.08mL0.42mL0.85mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet