Potentandselectiveinhibitorofhumanvascularendothelialgrowthfactorreceptor2(VEGFR-2/KDR)activity.SelectivelyinhibitsVEGFR-2(IC50=2nM)overVEGFR-1andarangeofotherreceptortyrosinekinasessuchasPDGFRβ,FGFR1,EGFRanderbB2(IC50>50μM).InhibitsVEGF-A-inducedendothelialcellproliferationinvitro(IC50=8nM).
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ZM323881hydrochlorideisalsoofferedaspartoftheTocriscreenPlusandTocriscreenKinaseInhibitorToolboxI.FindoutmoreaboutcompoundlibrariesavailablefromTocris.
M.Wt | 411.86 |
Formula | C22H18FN3O2.HCl |
Storage | Desiccateat+4°C |
Purity | ≥99%(HPLC) |
CASNumber | 193000-39-4 |
PubChemID | 22624897 |
InChIKey | AVRHWGLIYGJSOD-UHFFFAOYSA-N |
Smiles | Cl.CC1=C(O)C=C(NC2=C3C=CC(OCC4=CC=CC=C4)=CC3=NC=N2)C(F)=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
Solvent | MaxConc.mg/mL | MaxConc.mM | |
---|---|---|---|
Solubility | |||
DMSO | 20.59 | 50 |
Thefollowingdataisbasedontheproductmolecularweight411.86.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
---|---|---|---|
1mM | 2.43mL | 12.14mL | 24.28mL |
5mM | 0.49mL | 2.43mL | 4.86mL |
10mM | 0.24mL | 1.21mL | 2.43mL |
50mM | 0.05mL | 0.24mL | 0.49mL |