请使用支持JavaScript的浏览器!
主营:分子类,蛋白类,抗体类,生化类试剂
℡ 4000-520-616
℡ 4000-520-616
Tocris/ZM 323881 hydrochloride/2475/1/1 mg
产品编号:2475/1
市  场 价:¥2300.00
场      地:美国(厂家直采)
产品分类: 蛋白类>>激酶>
联系QQ:1570468124
电话号码:4000-520-616
邮      箱: info@ebiomall.com
美  元  价:$115.00
品      牌: Tocris
公      司:Tocris Bioscience
公司分类:
Tocris/ZM 323881 hydrochloride/2475/1/1 mg
商品介绍
Description:Potent,selectiveinhibitorofVEGFR-2
ChemicalName:5-((7-Benzyloxyquinazolin-4-yl)amino)-4-fluoro-2-methylphenolhydrochloride
Purity:≥99%(HPLC)
BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferences

BiologicalActivity

Potentandselectiveinhibitorofhumanvascularendothelialgrowthfactorreceptor2(VEGFR-2/KDR)activity.SelectivelyinhibitsVEGFR-2(IC50=2nM)overVEGFR-1andarangeofotherreceptortyrosinekinasessuchasPDGFRβ,FGFR1,EGFRanderbB2(IC50>50μM).InhibitsVEGF-A-inducedendothelialcellproliferationinvitro(IC50=8nM).

LicensingInformation

SoldwiththepermissionofAstraZenecaUKLtd.

CompoundLibraries

ZM323881hydrochlorideisalsoofferedaspartoftheTocriscreenPlusandTocriscreenKinaseInhibitorToolboxI.FindoutmoreaboutcompoundlibrariesavailablefromTocris.

TechnicalData

M.Wt411.86
FormulaC22H18FN3O2.HCl
StorageDesiccateat+4°C
Purity≥99%(HPLC)
CASNumber193000-39-4
PubChemID22624897
InChIKeyAVRHWGLIYGJSOD-UHFFFAOYSA-N
SmilesCl.CC1=C(O)C=C(NC2=C3C=CC(OCC4=CC=CC=C4)=CC3=NC=N2)C(F)=C1

Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.

AllTocrisproductsareintendedforlaboratoryresearchuseonly.

SolubilityData

SolventMaxConc.mg/mLMaxConc.mM
Solubility
DMSO20.5950

PreparingStockSolutions

Thefollowingdataisbasedontheproductmolecularweight411.86.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.

Concentration/SolventVolume/Mass1mg5mg10mg
1mM2.43mL12.14mL24.28mL
5mM0.49mL2.43mL4.86mL
10mM0.24mL1.21mL2.43mL
50mM0.05mL0.24mL0.49mL

ProductDatasheets

CertificateofAnalysis/ProductDatasheet
SafetyDatasheet