Inhibitorofvascularendothelialgrowthfactor(VEGF)receptortyrosinekinase.InhibitsactivityofKDRandFLTVEGFreceptors(IC50valuesare100nMand2μMrespectively)anddisplays>3-foldselectivityoverFGFR-1.Orallyactiveinvivo.
SoldwiththepermissionofAstraZenecaUKLtd.
| M.Wt | 370.21 |
| Formula | C16H13N3O2FCl.HCl |
| Storage | DesiccateatRT |
| Purity | ≥99%(HPLC) |
| CASNumber | 196603-47-1 |
| PubChemID | 21701577 |
| InChIKey | SCUXIROMWPQVJO-UHFFFAOYSA-N |
| Smiles | Cl.COC1=C(OC)C=C2C(NC3=CC=C(Cl)C=C3F)=NC=NC2=C1 |
Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.
AllTocrisproductsareintendedforlaboratoryresearchuseonly.
| Solvent | MaxConc.mg/mL | MaxConc.mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 3.7 | 10 |
Thefollowingdataisbasedontheproductmolecularweight370.21.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.
| Concentration/SolventVolume/Mass | 1mg | 5mg | 10mg |
|---|---|---|---|
| 1mM | 2.7mL | 13.51mL | 27.01mL |
| 5mM | 0.54mL | 2.7mL | 5.4mL |
| 10mM | 0.27mL | 1.35mL | 2.7mL |
| 50mM | 0.05mL | 0.27mL | 0.54mL |



